The INTERHEART study, a large global case-control study on risk factors for acute myocardial infarction, identified which single risk factor as contributing the LARGEST population attributable risk (PAR%) for MI?

• A Hypertension
• B Dyslipidaemia (raised ApoB/ApoA1 ratio) ✓
• C Diabetes mellitus
• D Cigarette smoking

Explanation

The INTERHEART study (Yusuf et al., Lancet 2004) — conducted across 52 countries — found that the ApoB/ApoA1 ratio (dyslipidaemia) had the highest population-attributable risk for acute MI (PAR 49.2%), followed by smoking (PAR 35.7%), psychosocial factors (PAR 32.5%), diabetes (PAR 9.9%), and hypertension (PAR 17.9%). Combined, nine modifiable risk factors accounted for over 90% of MI risk across all geographic, ethnic, and gender groups — demonstrating universality of cardiovascular risk factors.

Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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