In the INTERHEART study (52 countries), which modifiable risk factor had the HIGHEST Population Attributable Risk percent (PAR%) for acute myocardial infarction?
- A Hypertension
- B Smoking
- C Abnormal lipids (ApoB/ApoA1 ratio) ✓
- D Abdominal obesity
Correct answer: C. Abnormal lipids (ApoB/ApoA1 ratio)
Explanation
In the INTERHEART study (Yusuf et al., Lancet 2004), abnormal lipids — quantified by ApoB/ApoA1 ratio — had the highest PAR% at approximately 49%, meaning nearly half of all acute MIs globally could be attributed to dyslipidaemia. Smoking had PAR% ~36%, abdominal obesity ~20%, and hypertension ~18%. The nine modifiable risk factors together accounted for >90% of MI risk across all regions, races, and sexes.
Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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