A 60-year-old woman is diagnosed with Stage IC high-grade serous ovarian carcinoma. She undergoes optimal debulking surgery. Which is the standard first-line adjuvant chemotherapy regimen?
- A Carboplatin alone
- B Carboplatin plus paclitaxel ✓
- C Cisplatin plus etoposide (BEP regimen)
- D Docetaxel plus bevacizumab
Correct answer: B. Carboplatin plus paclitaxel
Explanation
The standard first-line chemotherapy for epithelial ovarian carcinoma is carboplatin (AUC 5-6) plus paclitaxel (175 mg/m2) every 3 weeks for 6 cycles, established by GOG and ICON trials. BEP is used for germic cell tumors. Bevvacizumab is used in selected high-risk or advanced cases as maintenance, not as initial standard first-line combination.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
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