Which ovarian tumor is associated with Meigs syndrome and hyperestrogenism in postmenopausal women, and what is Meigs syndrome?
- A Fibrothecoma; ascites, pleural effusion, and hydrothorax associated with a solid ovarian fibroma ✓
- B Granulosa cell tumor; ascites and pleural effusion resolving after tumor removal
- C Brenner tumor; ascites with right-sided hydrothorax
- D Fibrosarcoma; bilateral pleural effusion and ascites
Correct answer: A. Fibrothecoma; ascites, pleural effusion, and hydrothorax associated with a solid ovarian fibroma
Explanation
Meigs syndrome classically refers to the triad of a solid benign ovarian tumor (fibroma or fibrothecoma), ascites, and hydrothorax (usually right-sided) — all of which resolve after tumor removal. Fibrothecoma contains both fibrous and theca cells; the theca component produces estrogens causing endometrial hyperplasia or postmenopausal bleeding. Granulosa cell tumors also produce estrogen but Meigs syndrome is specifically associated with ovarian fibromas/fibrothecomas.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
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