A 45-year-old woman with a history of endometriosis presents with a 9 cm unilocular ovarian cyst with solid areas. Histopathology shows clear cells with hobnail nuclei and abundant eosinophilic cytoplasm. Which ovarian carcinoma subtype is MOST strongly associated with endometriosis?
- A Both endometrioid and clear cell carcinoma are equally associated ✓
- B Endometrioid carcinoma
- C Clear cell carcinoma
- D High-grade serous carcinoma
Correct answer: A. Both endometrioid and clear cell carcinoma are equally associated
Explanation
Both endometrioid and clear cell carcinomas of the ovary are strongly associated with endometriosis (present in approximately 20-30% of cases), and they can coexist with endometrial carcinoma. The association is comparable for both subtypes. High-grade serous carcinoma originates from tubal fimbriae/STIC and is not linked to endometriosis.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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