A 28-year-old woman presents with progressive hirsutism, deepening of voice, and clitoral enlargement over 6 months. Imaging shows a 7 cm solid left ovarian mass. Serum testosterone is markedly elevated. Which ovarian tumor is MOST likely?
- A Fibroma
- B Dysgerminoma
- C Sertoli-Leydig cell tumor ✓
- D Thecoma
Correct answer: C. Sertoli-Leydig cell tumor
Explanation
Sertoli-Leydig cell tumors (arrhenoblastomas) are sex cord-stromal tumors that secrete androgens, producing virilization (hirsutism, voice deepening, clitoromegaly) and elevated testosterone. They are usually unilateral and benign or low-grade. Fibromas and thecomas are estrogenic or non-functioning. Dysgerminoma does not secrete androgens.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.