A 35-year-old woman with known Peutz-Jeghers syndrome presents with a 4 cm ovarian mass. Histology shows prominent annular tubular structures with central calcification. Which ovarian tumor is most strongly associated with this syndrome?

• A Brenner tumor
• B Granulosa cell tumor
• C Sertoli-Leydig cell tumor
• D Sex cord tumor with annular tubules (SCTAT) ✓

Explanation

Sex cord tumor with annular tubules (SCTAT) is the ovarian tumor characteristically associated with Peutz-Jeghers syndrome. When SCTAT occurs in Peutz-Jeghers syndrome, it is typically benign, small, bilateral, calcified, and discovered incidentally. In sporadic cases, SCTAT behaves more aggressively. The annular tubules with central calcification are the defining histological feature.

Reference: WHO Classification of Tumours: Female Genital Tumours, 5th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.