A 20-year-old woman presents with hirsutism, deepening of voice, and clitoromegaly. A solid 5 cm left ovarian mass is found. Serum testosterone is markedly elevated. Which ovarian tumor is most likely responsible?

• A Granulosa cell tumor
• B Brenner tumor
• C Dysgerminoma
• D Sertoli-Leydig cell tumor ✓

Explanation

Sertoli-Leydig cell tumors (androblastomas) are sex cord-stromal tumors that secrete androgens, producing virilization: hirsutism, voice deepening, and clitoromegaly with elevated testosterone. Granulosa cell tumors produce estrogen, not androgens. Dysgerminoma is a germ cell tumor typically not hormonally active. Brenner tumors are non-functioning.

Reference: Williams Gynecology, 4th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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