Which ovarian tumor is most frequently associated with synchronous endometrial adenocarcinoma due to its estrogen-secreting property?

• A Brenner tumor
• B Fibroma
• C Sertoli-Leydig cell tumor
• D Granulosa cell tumor ✓

Explanation

Adult granulosa cell tumors secrete estrogen, which stimulates endometrial proliferation leading to endometrial hyperplasia in about 25% of cases and endometrial adenocarcinoma in roughly 5-10%. Sertoli-Leydig tumors secrete androgens causing virilization. Fibromas are hormonally inactive and present with Meigs syndrome. Brenner tumors are usually benign and non-functioning.

Reference: Williams Gynecology, 4th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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