Grading of an immature ovarian teratoma, which determines the need for postoperative chemotherapy, is based on:

• A Mitotic count per ten high power fields
• B Proportion of the tumour occupied by immature neuroectodermal tissue ✓
• C Degree of nuclear atypia in mature cartilage
• D Presence of yolk sac elements within the tumour

Explanation

Immature teratomas are graded by the Norris system according to the quantity of immature neuroectodermal tissue: Grade 1 has rare foci limited to one low power field per slide, Grade 2 has more but under three fields, and Grade 3 has extensive sheets. Grade 1 tumours confined to the ovary may be managed by surgery alone, whereas Grades 2 and 3 receive multiagent chemotherapy. Mitotic counts and cartilage atypia do not define the grade.

Reference: Berek and Novak's Gynecology, 16th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.