Which epithelial ovarian carcinoma is characteristically associated with endometriosis, shows hobnail-shaped cells with clear cytoplasm on histology, and is relatively resistant to platinum-based chemotherapy?
- A Clear cell carcinoma ✓
- B Low-grade serous carcinoma
- C Mucinous carcinoma
- D Endometrioid adenocarcinoma
Correct answer: A. Clear cell carcinoma
Explanation
Clear cell carcinoma arises in up to a quarter of cases from an endometriotic focus, displays tubulocystic architecture with hobnail cells having bulbous nuclei protruding into lumina, and carries the worst prognosis among epithelial subtypes because it responds poorly to carboplatin-paclitaxel. Endometrioid carcinoma also associates with endometriosis, but it shows glandular morphology resembling uterine endometrioid tumours and is chemosensitive.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.