A 6-year-old girl presents with breast development, pubic hair and accelerated growth. Ultrasound shows a 9 cm solid-cystic left ovarian mass. Serum oestradiol is markedly elevated and AFP is normal. Histology would most likely show which pattern?
- A Call-Exner bodies in a diffuse sheet of granulosa cells
- B Reticular pattern with primitive glomeruloid structures
- C Follicles of varying size lined by luteinised granulosa cells with abundant eosinophilic cytoplasm ✓
- D Sheets of large uniform germ cells with lymphocytic infiltrate
Correct answer: C. Follicles of varying size lined by luteinised granulosa cells with abundant eosinophilic cytoplasm
Explanation
Juvenile granulosa cell tumour is the commonest cause of ovarian tumour-associated isosexual precocious puberty in children. It shows follicles of varying size filled with basophilic fluid and lined by luteinised granulosa cells with abundant eosinophilic cytoplasm. Call-Exner bodies typify the adult granulosa cell tumour seen in peri- and postmenopausal women, while option D describes dysgerminoma.
Reference: Williams Gynecology, 4th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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