A 19-year-old woman presents with amenorrhoea, hirsutism, deepening voice and clitoromegaly. Imaging shows a 7 cm unilateral solid ovarian mass. Intraoperatively there is no ascites or spread. Which tumour is the most likely cause of her virilisation?
- A Adult granulosa cell tumour
- B Sertoli-Leydig cell tumour ✓
- C Fibrothecoma
- D Dysgerminoma
Correct answer: B. Sertoli-Leydig cell tumour
Explanation
Sertoli-Leydig cell tumours (androblastomas) typically occur in young women and produce androgens causing virilisation; Leydig cells contain Reinke crystals on electron microscopy or crystalloids on histology. Granulosa cell tumours and fibrothecomas are oestrogenic and cause endometrial hyperplasia or bleeding, not virilisation. Dysgerminoma is generally non-functional apart from rare hCG secretion.
Reference: Williams Gynecology, 4th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.