Which histological subtype of epithelial ovarian carcinoma is most strongly associated with pre-existing endometriosis and is characterised by hobnail cells lining tubulocystic spaces?

• A Clear cell carcinoma ✓
• B High-grade serous carcinoma
• C Endometrioid adenocarcinoma
• D Mucinous carcinoma

Explanation

Ovarian clear cell carcinoma arises in up to a third of cases from an endometriotic focus, shows sheets and tubulocystic patterns with hobnail cells having bulbous nuclei protruding into lumina, and carries ARID1B mutations. Endometrioid carcinoma also associates with endometriosis, but its hallmark is squamous morular metaplasia and glands resembling endometrial adenocarcinoma, not hobnail clear cells.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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