A 42-year-old woman has bilateral solid ovarian masses discovered on evaluation of gastric complaints. Upper GI endoscopy reveals a linitis plastica type gastric carcinoma. Histology of the ovarian masses shows nests of signet ring cells within a cellular sarcoma-like stroma. What is the diagnosis?

• A Primary mucinous ovarian carcinoma
• B Granulosa cell tumour
• C Brenner tumour
• D Krukenberg tumour ✓

Explanation

Krukenberg tumour is a metastatic ovarian malignancy containing mucin-filled signet ring cells, classically from gastric carcinoma and often bilateral. Primary mucinous ovarian carcinoma forms glands and cysts lined by atypical mucinous epithelium rather than diffuse signet ring infiltration. Bilaterality plus a known primary elsewhere points away from any primary ovarian neoplasm.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.