Following fertility-sparing surgery for a Stage II malignant ovarian germ cell tumour in a 16-year-old girl, the standard adjuvant chemotherapy regimen is:
- A Bleomycin, etoposide and cisplatin ✓
- B Carboplatin and paclitaxel
- C Vincristine, actinomycin D and cyclophosphamide
- D Methotrexate, actinomycin D and cyclophosphamide
Correct answer: A. Bleomycin, etoposide and cisplatin
Explanation
BEP, consisting of bleomycin, etoposide and cisplatin given every 21 days, is the standard adjuvant regimen for malignant ovarian germ cell tumours beyond early-stage disease and mirrors the regimen proven in testicular germ cell cancer. VAC was the older regimen now largely replaced due to superior BEP cure rates. Carboplatin-paclitaxel is the backbone for epithelial ovarian cancer, and MAC is used in gestational trophoblastic disease.
Reference: Williams Gynecology, 3rd ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.