A somatic missense mutation found in more than 90 percent of adult-type granulosa cell tumours of the ovary is located in which gene?

• A PTPN11
• B KRAS
• C DICER1
• D FOXL2 ✓

Explanation

The recurrent c.402C greater than G missense mutation in FOXL2, a transcription factor essential for granulosa cell development, is present in approximately 95 percent of adult granulosa cell tumours and is virtually absent in other ovarian neoplasms. DICER1 mutations characterise Sertoli-Leydig cell tumours and embryonal rhabdomyosarcoma of the cervix. KRAS mutations occur in borderline and low-grade serous tumours.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.