Which serum marker is used both to monitor treatment response and detect recurrence in a woman operated for an adult granulosa cell tumour of the ovary?
- A LDH
- B CA-125
- C Inhibin B ✓
- D CEA
Correct answer: C. Inhibin B
Explanation
Granulosa cell tumours secrete inhibin, and inhibin B in particular is a sensitive postoperative surveillance marker for detecting residual disease and recurrence, which can occur decades after initial surgery. CA-125 reflects epithelial ovarian cancer and is often normal in sex cord-stromal tumours. LDH is the marker for dysgerminoma and CEA for mucinous and gastrointestinal primaries.
Reference: Williams Gynecology, 3rd ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.