Histological examination of a solid-cystic ovarian mass from a 58-year-old woman shows nests of transitional-type epithelium with longitudinal grooves in oval nuclei, surrounded by dense fibrous stroma. Adjacent ovarian parenchyma contains a separate mucinous cystadenoma. What is this tumour?

• A Adult granulosa cell tumour
• B Clear cell carcinoma
• C Serous adenofibroma
• D Brenner tumour ✓

Explanation

The described features are diagnostic of Brenner tumour, a benign surface epithelial-stromal tumour with transitional (urothelial-like) differentiation. The characteristic nuclear grooves give the classic coffee bean appearance. About 10 to 30 percent of Brenner tumours are found adjacent to a mucinous cystadenoma, supporting a shared origin from Walthard rests. Clear cell carcinoma shows hobnail cells, and granulosa cell tumours lack transitional nests.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.