A 52-year-old woman presents with abdominal bloating and a pelvic mass. Examination shows bilateral firm ovarian enlargement. Histology reveals ovarian tissue infiltrated by signet ring cells containing intracytoplasmic mucin, set in a cellular stroma. Which primary site is MOST likely?
- A Stomach ✓
- B Colon
- C Breast
- D Pancreas
Correct answer: A. Stomach
Explanation
Krukenberg tumour is defined as an ovarian metastasis containing mucin-filled signet ring cells within a sarcoma-like stromal proliferation. The classic and most common primary is the stomach, followed by colon, appendix and breast. Bilateral involvement occurs in over two thirds of cases. Breast carcinoma does metastasise to ovary, particularly lobular type, but it lacks the signet ring morphology that defines this entity.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.