Which histological feature determines the grading of an immature ovarian teratoma?

• A Proportion of thyroid tissue present
• B Degree of keratinisation within squamous elements
• C Number of mitoses in cartilaginous tissue
• D Amount of immature neuroectodermal tissue per unit area ✓

Explanation

Immature teratomas are graded 1 to 3 according to the quantity of immature neuroectodermal tissue, assessed as the number of low-power fields occupied by primitive neural tissue per slide. Grade correlates with risk of recurrence and extraovarian spread and guides the need for chemotherapy beyond stage IA disease. Mature elements such as skin, cartilage, and thyroid do not determine grade, since their presence defines maturity rather than immaturity of the tumour.

Reference: Williams Gynecology, 4th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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