A 52-year-old woman undergoes oophorectomy for an incidental 3 cm solid ovarian nodule. Histology shows nests of transitional-type epithelium resembling urothelium, set in dense fibrous stroma. The nuclei show longitudinal grooves. What is the diagnosis?

• A Brenner tumour ✓
• B Fibroma
• C Serous cystadenofibroma
• D Granulosa cell tumour

Explanation

The Brenner tumour is composed of nests of transitional (urothelial-like) epithelium within abundant fibromatous stroma. The epithelial cells have pale cytoplasm and characteristic longitudinal nuclear grooves, giving the classic coffee bean appearance. Most are benign, solid, and small incidental findings. B fibroma lacks the epithelial nests, and a granulosa cell tumour shows Call-Exner bodies rather than urothelial differentiation.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.