Which ovarian tumor is characteristically associated with endometriosis, often bilateral, and shows hobnail cells with clear cytoplasm on histology?
- A High-grade serous carcinoma
- B Clear cell carcinoma ✓
- C Mucinous cystadenocarcinoma
- D Adult granulosa cell tumor
Correct answer: B. Clear cell carcinoma
Explanation
Clear cell carcinoma of the ovary is associated with endometriosis, is often bilateral, and characterized by hobnail cells with bulging nuclei and clear cytoplasm. It is one of the major types of endometriosis-associated ovarian cancer along with endometrioid carcinoma. High-grade serous carcinoma is the most common epithelial tumor but is not defined by hobnail cells. Mucinous carcinoma shows mucin-filled cells. Granulosa cell tumor is a sex cord-stromal tumor with coffee-bean nuclei.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.