A 20-year-old woman has a 12 cm ovarian mass with elevated serum LDH and normal AFP and beta-hCG. Histology shows large uniform cells with clear cytoplasm and prominent nuclei arranged in nests separated by fibrous septa containing lymphocytes. What is the diagnosis?

• A Yolk sac tumor
• B Choriocarcinoma
• C Embryonal carcinoma
• D Dysgerminoma ✓

Explanation

Dysgerminoma is the ovarian counterpart of testicular seminoma. Histology shows nests of large uniform cells with clear cytoplasm and central nuclei, with fibrous septa containing lymphocytes. LDH is characteristically elevated, while AFP is normal. AFP elevation would suggest a yolk sac component. Beta-hCG is markedly elevated in choriocarcinoma.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.