A 45-year-old woman undergoes oophorectomy for a 9 cm ovarian mass. Histology reveals cells arranged in a coffee-bean pattern with longitudinal nuclear grooves. Which tumor is most likely?
- A Adult granulosa cell tumor ✓
- B Brenner tumor
- C Endometrioid carcinoma
- D Krukenberg tumor
Correct answer: A. Adult granulosa cell tumor
Explanation
Adult granulosa cell tumors characteristically show coffee-bean nuclei with longitudinal nuclear grooves, a hallmark microscopic finding. These are sex cord-stromal tumors that secrete estrogen. Brenner tumors show transitional cell nests, endometrioid carcinoma resembles endometrial adenocarcinoma, and Krukenberg tumor shows signet-ring cells from a gastrointestinal primary.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.