Which statement correctly distinguishes non-gestational ovarian choriocarcinoma from gestational choriocarcinoma?

• A Non-gestational choriocarcinoma is more chemosensitive and carries a better prognosis
• B Non-gestational choriocarcinoma frequently occurs as a component of mixed germ cell tumours and carries a poorer prognosis ✓
• C Gestational choriocarcinoma lacks cytotrophoblast and syncytiotrophoblast
• D Both types arise exclusively from ovarian germ cells

Explanation

Pure non-gestational choriocarcinoma of the ovary is rare; it more often appears as a component of mixed germ cell tumours alongside dysgerminoma or yolk sac tumour. Compared with gestational choriocarcinoma, it is relatively chemotherapy resistant and carries a worse prognosis, so surgery plus multiagent chemotherapy is required. Both types contain cytotrophoblast and syncytiotrophoblast and secrete beta-hCG, but gestational choriocarcinoma originates from a pregnancy event, not from germ cells.

Reference: Berek and Novak's Gynecology, 16th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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