A 17-year-old girl presents with amenorrhoea, deepening voice, acne and clitoromegaly of 8 months duration. Ultrasound shows a 7 cm solid right ovarian mass. Testosterone is markedly elevated. The tumour most likely to account for this presentation contains which histological feature?

• A Call-Exner bodies
• B Schiller-Duval bodies
• C Reinke crystals in Leydig cells ✓
• D Psammoma bodies

Explanation

Virilisation with a solid ovarian mass in a teenager points to Sertoli-Leydig cell tumour (androblastoma), a sex cord-stromal tumour producing androgens. Pure Leydig cell components show Reinke crystals, the diagnostic feature. Call-Exner bodies belong to granulosa cell tumours, which produce oestrogen and cause bleeding or precocious puberty rather than virilisation. Schiller-Duval bodies indicate yolk sac tumour, and psammoma bodies indicate serous carcinoma.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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