A 48-year-old woman undergoes oophorectomy for an incidental solid ovarian nodule. Histology shows nests of transitional-type epithelial cells with longitudinal grooving of the nuclei, set in dense fibrous stroma. Which statement about this tumour is correct?
- A It is almost always bilateral and malignant
- B It may be associated with a coexisting mucinous cystadenoma in the same ovary ✓
- C It secretes inhibin B and causes precocious puberty
- D It arises from granulosa cells of the follicular apparatus
Correct answer: B. It may be associated with a coexisting mucinous cystadenoma in the same ovary
Explanation
The description is classic for Brenner tumour, a benign surface epithelial-stromal tumour showing urothelial (transitional) differentiation with characteristic coffee bean nuclei. About 10 to 15 percent are associated with a mucinous cystadenoma in the same ovary, supporting the theory of shared origin from transitional metaplasia of the surface epithelium. It is usually unilateral, solid, and almost always benign. It does not secrete hormones and is unrelated to granulosa cells.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.