A 42-year-old woman presents with rapid abdominal distension. Examination reveals bilateral solid ovarian masses. Biopsy of one mass shows diffuse infiltration by mucin-filled signet ring cells within a cellular stroma. Upper gastrointestinal endoscopy reveals an ulcerated lesion in the pyloric antrum. What is the correct term for these ovarian masses?
- A Primary bilateral mucinous adenocarcinoma
- B Krukenberg tumour ✓
- C Pseudomyxoma ovarii
- D Clear cell carcinoma, bilateral
Correct answer: B. Krukenberg tumour
Explanation
Krukenberg tumour is defined as a metastatic ovarian malignancy containing signet ring cells, classically from a gastric primary, and characteristically produces bilateral solid ovarian enlargement with preserved ovarian shape. Primary mucinous ovarian carcinomas show invasive glands rather than diffusely scattered signet ring cells, and pseudomyxoma peritonei is associated with appendiceal mucinous lesions rather than this ovarian picture.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.