According to the dualistic model of ovarian carcinogenesis, low-grade serous carcinomas typically arise from which precursor lesion and harbor which molecular alteration?
- A Borderline serous tumor; KRAS or BRAF mutation ✓
- B Serous tubal intraepithelial carcinoma; TP53 mutation
- C Endometrioid cyst; PTEN mutation
- D Mucinous cystadenoma; HER2 amplification
Correct answer: A. Borderline serous tumor; KRAS or BRAF mutation
Explanation
Low-grade serous carcinomas develop via the slow pathway from borderline serous tumors and harbor KRAS or BRAF mutations. High-grade serous carcinomas arise from serous tubal intraepithelial carcinoma (STIC) with TP53 mutations. Endometrioid carcinomas arise from endometriosis with PTEN or ARID1B mutations. The dualistic model is a fundamental concept in ovarian cancer classification.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.