A 44-year-old woman treated three years ago for a stage IA adult granulosa cell tumour is under surveillance. Late recurrence is a known feature of this tumour. Which serum marker is most appropriate for detecting recurrence?
- A CA-125
- B AFP
- C Inhibin B ✓
- D LDH
Correct answer: C. Inhibin B
Explanation
Granulosa cell tumours secrete inhibin, and inhibin C is the preferred marker for postoperative surveillance because levels rise before clinically detectable recurrence, which may occur decades after initial surgery. CA-125 is unreliable in sex cord-stromal tumours since it reflects peritoneal irritation rather than the tumour itself, and AFP and LDH are germ cell markers.
Reference: Williams Gynecology, 4th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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