A 48-year-old woman presents with bilateral solid ovarian masses discovered incidentally. Biopsy shows ovaries diffusely infiltrated by mucin-filled signet ring cells with hyperchromatic nuclei pushed to the periphery. The most likely primary site is:
- A Stomach ✓
- B Appendix
- C Colon
- D Breast
Correct answer: A. Stomach
Explanation
Krukenberg tumour is defined as a metastatic ovarian tumour containing mucin-filled signet ring cells, and the stomach is the classic primary site, followed by colon, appendix, and breast. Bilateral involvement with preserved ovarian shape is characteristic. Pseudomyxoma peritonei, by contrast, is associated with appendiceal mucinous tumours and does not show signet ring morphology.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.