Histopathology of an ovarian tumour in a 16-year-old girl shows a malignant epithelial structure consisting of a central capillary space surrounded by tumour cells, projecting into a cystic space lined by flattened tumour cells. This finding is diagnostic of:
- A Clear cell carcinoma
- B Embryonal carcinoma
- C Yolk sac tumour ✓
- D Immature teratoma
Correct answer: C. Yolk sac tumour
Explanation
The Schiller-Duval body, a glomerulus-like structure with a central vessel covered by tumour cells projecting into a space lined by flattened cells, is pathognomonic of yolk sac (endodermal sinus) tumour. These tumours occur in girls and young women and secrete AFP. Clear cell carcinoma shows hobnail cells and hyaline globules but not Schiller-Duval bodies.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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