A 19-year-old girl presents with amenorrhoea, deepening voice, and clitoromegaly of 6 months duration. Ultrasound shows a 9 cm solid right ovarian mass. Tumour cells show tubules resembling testicular seminiferous tubules, and some stromal cells contain Reinke crystals. The most likely diagnosis is:

• A Gonadoblastoma
• B Leydig cell tumour (pure)
• C Adult granulosa cell tumour
• D Sertoli-Leydig cell tumour ✓

Explanation

Sertoli-Leydig cell tumour (androblastoma) occurs in young women and causes virilisation through androgen secretion. The presence of both Sertoli cells forming tubules and Leydig cells containing Reinke crystals confirms the mixed pattern. D pure Leydig cell tumour has no tubular component, and granulosa cell tumours cause oestrogenic rather than androgenic manifestations.

Reference: Williams Gynecology, 4th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.