Histology of an incidental solid-cystic ovarian nodule removed at hysterectomy shows nests of transitional-type epithelial cells with longitudinal grooves in oval nuclei ('coffee-bean' appearance) set in dense fibrous stroma. Which tumour is this?
- A Granulosa cell tumour
- B Fibroma
- C Brenner tumour ✓
- D Serous adenofibroma
Correct answer: C. Brenner tumour
Explanation
The Brenner tumour is composed of urothelial (transitional)-type nests with characteristic grooved 'coffee-bean' nuclei within abundant fibromatous stroma. It is almost always benign and frequently coexists with a mucinous cystadenoma in the same ovary. Granulosa cell tumours show Call-Exner bodies, and fibroma lacks an epithelial component entirely.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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