What histological feature determines the grade of an immature ovarian teratoma according to the conventional three-tier system?
- A Proportion of mature cartilage relative to epithelium
- B Amount of immature neuroepithelial tissue per low-power field ✓
- C Degree of cytological atypia in the squamous component
- D Mitotic count in the mesenchymal element
Correct answer: B. Amount of immature neuroepithelial tissue per low-power field
Explanation
Immature teratomas are graded by quantifying immature neuroepithelial (neuroectodermal) tissue: grade 1 has rare foci limited to one low-power field per slide, grade 2 has up to three such fields, and grade 3 has extensive immature neural tissue occupying more than three low-power fields. Grade predicts recurrence risk and the need for adjuvant chemotherapy. Cytological atypia, mitoses in mature mesenchyme, and the amount of mature cartilage do not define grade.
Reference: Berek and Novak's Gynecology, 16th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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