A 42-year-old woman with known Lynch syndrome (mismatch repair gene mutation) is diagnosed with ovarian carcinoma. Which histological subtype pair is MOST characteristic of hereditary ovarian cancer in Lynch syndrome?
- A High-grade serous and carcinosarcoma
- B Endometrioid and clear cell carcinoma ✓
- C Mucinous and low-grade serous carcinoma
- D Dysgerminoma and yolk sac tumour
Correct answer: B. Endometrioid and clear cell carcinoma
Explanation
Lynch syndrome confers a lifetime ovarian cancer risk of roughly 10 to 12 percent, and the tumours are disproportionately endometrioid and clear cell types, often arising in endometriosis and presenting at earlier stage than sporadic disease. High-grade serous carcinoma is linked instead to BRCA1 and BRCA2 mutations. Mucinous and low-grade serous tumours are not part of any established hereditary ovarian cancer syndrome.
Reference: Williams Gynecology, 4th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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