Which histological feature is characteristic of an ovarian Brenner tumour?

• A Abundant psammoma bodies within branching papillae
• B Nests of transitional-type urothelial epithelium with longitudinally grooved coffee-bean nuclei set in dense fibrous stroma ✓
• C Call-Exner bodies surrounding eosinophilic fluid
• D Signet ring cells infiltrating a desmoplastic stroma

Explanation

Brenner tumour is a benign surface epithelial tumour showing well-circumscribed nests of transitional epithelium resembling urothelium, often with central microcystic change, embedded in densely fibrous stroma; the nuclei are grooved, giving a coffee-bean appearance. It is thought to arise from metaplasia related to Walthard cell rests. Psammomatous papillae suggest serous tumour, Call-Exner bodies suggest granulosa cell tumour, and signet ring cells indicate metastatic Krukenberg tumour.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

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Written and medically reviewed by the StethoPrep medical team.