Which molecular alteration provides the strongest mechanistic link between endometriosis and the development of ovarian clear cell carcinoma?

• A Inactivating mutation of ARID1A ✓
• B TP53 missense mutation
• C Activating KRAS mutation
• D BRCA1 promoter methylation

Explanation

ARID1B encodes a SWI/SNF chromatin remodelling subunit and is mutated in approximately half of ovarian clear cell carcinomas and their coexisting atypical endometriotic foci, supporting transformation from endometriosis. TP53 mutation is the hallmark of high-grade serous carcinoma. Activating KRAS mutations typify mucinous and low-grade serous tumours. This pathway distinction between type I and type II tumours is heavily examined.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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