A 48-year-old woman undergoing hysterectomy for fibroids has an incidental firm 3 cm ovarian nodule. Microscopy shows well-demarcated nests of urothelium-like transitional cells with longitudinal nuclear grooves embedded in dense fibrous stroma, with no atypia. What is the diagnosis, and with which other lesion is this tumour frequently associated?
- A Fibroma, associated with Meigs syndrome
- B Thecoma, associated with endometrial hyperplasia
- C Benign Brenner tumour, frequently associated with mucinous cystadenoma ✓
- D Serous cystadenofibroma, associated with BRCA mutation
Correct answer: C. Benign Brenner tumour, frequently associated with mucinous cystadenoma
Explanation
Brenner tumours are mostly benign surface epithelial tumours showing transitional-type epithelium thought to arise from metaplasia of coelomic epithelium or ovarian Walthard rests. The coffee bean nucleus with a longitudinal groove is classic, and about 20 to 30 percent coexist with a mucinous cystadenoma in the same or contralateral ovary. A fibroma lacks epithelial nests, and a thecoma luteinises and produces oestrogen.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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