Histological examination of an ovarian tumour from a 16-year-old girl reveals a reticular and microcystic pattern with eosinophilic hyaline globules, and structures composed of a central capillary surrounded by tumour cells projecting into a space lined by flattened cells. Which structure was described?
- A Call-Exner body
- B Endodermal sinus (Schiller-Duval) body ✓
- C Rosette of neuroblastoma
- D Kivull body of dysgerminoma
Correct answer: B. Endodermal sinus (Schiller-Duval) body
Explanation
The Schiller-Duval body, a glomerulus-like central vessel sheathed by tumour cells within a space, is characteristic of yolk sac (endodermal sinus) tumour, along with hyaline globules that contain alpha-fetoprotein. It is the most common malignant germ cell tumour in children and secretes AFP, which is used for monitoring. Call-Exner bodies occur in granulosa cell tumour, and dysgerminoma shows lymphocytic infiltrates without such structures.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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