A 22-year-old woman has a unilateral solid ovarian mass. Serum AFP is markedly elevated. Which tumour should be MOST suspected?
- A Endodermal sinus tumour (yolk sac tumour) ✓
- B Immature teratoma
- C Granulosa cell tumour
- D Choriocarcinoma
Correct answer: A. Endodermal sinus tumour (yolk sac tumour)
Explanation
Endodermal sinus (yolk sac) tumour is a malignant germ cell tumour seen in young women that secretes AFP; Schiller-Duval bodies are its pathognomonic histological feature. Immature teratoma elevates AFP mildly but is primarily characterised by immature neuroepithelium. Granulosa cell tumour secretes inhibin/oestrogen, and choriocarcinoma elevates beta-hCG.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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