Which ovarian tumour is characterised by 'Call-Exner bodies' on histology and commonly presents with features of oestrogen excess such as endometrial hyperplasia?

• A Sertoli–Leydig cell tumour
• B Thecoma
• C Dysgerminoma
• D Granulosa cell tumour ✓

Explanation

Granulosa cell tumours are sex-cord stromal tumours that secrete oestrogen, causing endometrial hyperplasia or carcinoma, and are characterised histologically by Call-Exner bodies (small follicle-like structures with eosinophilic secretion). They also secrete inhibin and AMH, which are useful tumour markers. Sertoli–Leydig tumours cause virilisation; thecomas are oestrogenic but lack Call-Exner bodies; dysgerminoma is a germ cell tumour with LDH as marker.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.