Which ovarian tumor is characterized histologically by Call-Exner bodies and is associated with estrogenic manifestations including endometrial hyperplasia?
- A Sertoli-Leydig cell tumor
- B Granulosa cell tumor ✓
- C Brenner tumor
- D Thecoma
Correct answer: B. Granulosa cell tumor
Explanation
Granulosa cell tumor is a sex cord-stromal tumor that secretes estrogen and contains Call-Exner bodies — small spaces between granulosa cells filled with eosinophilic fluid arranged in rosette patterns. The estrogenic excess causes endometrial hyperplasia, abnormal uterine bleeding, and rarely endometrial carcinoma. Sertoli-Leydig cell tumors produce androgens causing virilization. Thecoma also produces estrogen but lacks Call-Exner bodies. Brenner tumor has transitional epithelium and is hormonally inactive.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.