Which ovarian tumor is associated with Sertoli-Leydig cell tumor and produces virilizing symptoms most characteristically in women under 30 years?
- A Granulosa cell tumor (adult type)
- B Thecoma
- C Androblastoma ✓
- D Gynandroblastoma
Correct answer: C. Androblastoma
Explanation
Androblastoma (Sertoli-Leydig cell tumor) is the classic virilizing ovarian tumor occurring predominantly in women under 30. It secretes testosterone and androgens causing defeminization followed by virilization (clitoromegaly, hirsutism, voice deepening, amenorrhea). Granulosa cell tumors produce estrogen causing feminizing effects. Thecomas are also estrogenic. Gynandroblastoma is exceedingly rare with both granulosa and Sertoli-Leydig components. Androblastoma is the textbook answer for virilizing ovarian tumor in young women.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.