Granulosa cell tumor of the ovary characteristically secretes which hormone responsible for its feminizing effects and the associated endometrial pathology?
- A Progesterone
- B Estradiol ✓
- C Testosterone
- D Human chorionic gonadotropin
Correct answer: B. Estradiol
Explanation
Granulosa cell tumors are sex cord-stromal tumors that predominantly secrete estradiol, causing feminizing effects such as precocious puberty in children, menorrhagia in reproductive-age women, and postmenopausal bleeding. Chronic unopposed estrogen stimulation can cause endometrial hyperplasia or carcinoma. Call-Exner bodies are the hallmark histological finding.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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