Which ovarian germ cell tumour is associated with elevated serum AFP, contains Schiller-Duval bodies on histology, and has the WORST prognosis among pure germ cell tumours?
- A Endodermal sinus tumour (Yolk sac tumour) ✓
- B Dysgerminoma
- C Immature teratoma
- D Choriocarcinoma
Correct answer: A. Endodermal sinus tumour (Yolk sac tumour)
Explanation
Endodermal sinus tumour (yolk sac tumour) is characterised by markedly elevated serum AFP and the pathognomonic Schiller-Duval bodies (perivascular glomeruloid structures). It is the most aggressive pure germ cell tumour of the ovary with rapid growth and early metastasis. Dysgerminoma has excellent prognosis with BEP chemotherapy. Choriocarcinoma secretes β-hCG, not AFP. Immature teratoma is graded and has variable prognosis.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.