A Brenner tumour of the ovary is histologically characterised by nests of transitional-type epithelium embedded in a dense fibrous stroma. Which tumour marker, if any, is classically associated with malignant Brenner tumour?
- A Alpha-fetoprotein (AFP)
- B CA-125
- C No specific marker; Brenner tumours are generally marker-negative ✓
- D CA 19-9
Correct answer: C. No specific marker; Brenner tumours are generally marker-negative
Explanation
Brenner tumours are generally marker-negative; no single serum tumour marker is classically associated with them. AFP is associated with yolk sac tumours and hepatoid carcinomas. CA-125 is elevated in serous tumours. CA 19-9 is used for mucinous ovarian and gastrointestinal tumours. Brenner tumours are typically incidental findings and carry a good prognosis.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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