A 35-year-old woman with a granulosa cell tumour (GCT) of the ovary undergoes fertility-sparing surgery. Which hormonal marker is MOST useful for long-term surveillance for recurrence of adult GCT?
- A CA-125
- B Inhibin B ✓
- C Estradiol
- D AMH
Correct answer: B. Inhibin B
Explanation
Adult granulosa cell tumours produce inhibin B (a gonadal peptide hormone) which serves as a sensitive and specific tumour marker for surveillance after treatment. CA-125 is predominantly useful for epithelial ovarian cancers; estradiol may be elevated but is less specific; AMH is produced by GCTs but inhibin B has superior validation as a clinical surveillance marker.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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