Brenner tumor of the ovary is histologically characterised by nests of epithelial cells resembling which tissue type embedded in dense fibrous stroma?
- A Cervical columnar epithelium
- B Endometrial glandular epithelium
- C Urothelium (transitional epithelium) ✓
- D Serous epithelium with psamoma bodies
Correct answer: C. Urothelium (transitional epithelium)
Explanation
Brenner tumors are ovarian sex cord-stromal tumors with transitional cell (urothelial) differentiation. Histologically, they show characteristic 'coffee-bean' nuclei in epithelial cell nests (Walthard cell nests) resembling urothelium, set in a dense fibrous stroma. They are almost always benign, are often discovered incidentally, and may be associated with mucinous cystadenomas.
Reference: Shaw's Textbook of Gynaecology, 17th ed.
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